A truck loaded with strawberries flipped over at the highway 101 and highway 126 interchange.
It happened around 7 p.m. Thursday evening.
The big rig ended up in a deep gorge between the two roadways.
Crews said it could take hours to clean up the mess.
Ventura Fire Officials say the Eastbound transition on the 126 will be closed until Friday afternoon.
The driver was not seriously hurt.