The baby of the list, the St. John made its debut mere months ago in Maryland's capital.
Osteria 177 mixologist Lucien Smith, riffing on the classic sidecar recipe, mixed up a cocktail consisting of Louis XIII cognac, Grand Marnier Cuvee du Centenaire, Meyer lemon juice, syrup made from Meyer lemon and Grade 1 saffron and 23k edible gold flakes for garnish.
So far, Smith says they've sold two of 'em.
El Series (El Gaucho, Portland, Oregon)
The bar staff at El Gaucho Portland first made its name in the extravagant cocktails game with The Josephine, a $500 cocktail featuring L'Esprit de Courvoisier and Grand Marnier 150.
Once the bar's stash of L'Esprit de Courvoisier ran out, The Josephine was retired, but its siblings in the "El Series" have carried on the mantle.
A collection of four $220 cocktails, the El Series uses Louis XIII cognac as its base. Entries include the Louis Smash (add fresh mint and a splash of soda) and Louis Sidecar (add Grand Marnier, lemon and orange juices).
The JW 1800 (The Lily Bar & Lounge at The Bellagio, Las Vegas)
You've probably come across some member of the Johnnie Walker family in your lifetime, but have you ever met the Johnnie Walker?
You will if you order The Lily Bar's JW 1800.
This cocktail includes "The John Walker," an incredibly rare vintage whiskey that dates to the 1800s.
When we say incredibly rare, we mean it: only 180 bottles exist and once they run out, that's it.
In case you're interested in sipping this endangered species, the JW 1800 also includes sweet vermouth, whiskey-barrel-aged bitters and a Maraschino cherry.
Drinking the Stars (The Starlight Room, San Francisco)
You could easily buy a whole constellation of stars for the price of The Starlight Room's "Drinking the Stars" cocktail.
Originally created by mixologist Jacques Bezuidenhout, the concoction takes 1979 Chateau de Ravignan Bas Armagnac brandy and infuses it with Madagascar vanilla bean, orange peel and raisins.
It's topped off with Dom Perignon, and they'll even leave the bottle with you.
Order a 750 ml version of this drink for $365, or play high roller with the $735 1.5L.
If vanilla bean isn't your bag, the Starlight Room has three more so-called "million dollar cocktails," ranging from $90 to $200.
The $1K and Over Club
All the flashy cocktails above are built on nothing but booze and edible garnishes, but if you're looking for something that comes with a keepsake, there are plenty of even pricier contenders.